文献-子宫内膜癌-单细胞与空间转录组联合分享
文献-子宫内膜癌-单细胞与空间转录组联合分享
文献：
Yu X, Xie L, Ge J, Li H, Zhong S, Liu X. Integrating single-cell RNA-seq and spatial transcriptomics reveals MDK-NCL dependent immunosuppressive environment in endometrial carcinoma. Front Immunol. 2023 Apr 4;14:1145300. doi: 10.3389/fimmu.2023.1145300. PMID: 37081869; PMCID: PMC10110842.
数据：
单细胞：Single-cell RNA-seq (scRNA-seq) data for 5 patients with EAC (GSE173682)
空间转录组：spatial transcriptomic data for one patient with EC (GSM6177623 in GSE203612) were downloaded from Gene Expression Omnibus (GEO).
TCGA数据：TCGA-UCEC project from TCGA (https://portal.gdc.cancer.gov, accessed November 2022),
GEO验证数据集：EC patients from GEO (GSE120490) (15) and used as validation dataset.
分析方法：
1.单细胞标准分析：
2.内皮细胞亚群单独分析
3.上皮细胞亚群分析
4.细胞通讯分析
- 发表于 2023-09-19 21:58
- 阅读 ( 1009 )
- 分类：TCGA
