肿瘤的TNM分期讲解(stage)

肿瘤的TNM分期讲解(stage)

TCGA数据库中临床数据的TNM分期,及病理分期如下:

submitter_idajcc_pathologic_najcc_pathologic_majcc_pathologic_stageajcc_pathologic_t
TCGA-3M-AB46N0MXStage IBT2b
TCGA-3M-AB47N2MXStage IIIBT3
TCGA-B7-5816N0M0Stage IIBT4a
TCGA-B7-5818N0M0Stage IBT2
TCGA-B7-A5TIN3M0Stage IIICT4
TCGA-B7-A5TJNXM0Stage IIBT4a
TCGA-B7-A5TKNAM0Stage IIIAT4
TCGA-B7-A5TNNXM0Stage IIBT4a
TCGA-BR-4183N1M0Stage IIIAT3
TCGA-BR-4184N1MXStage IIIAT3
TCGA-BR-4253N1M0Stage IIIAT3
TCGA-BR-4255N1M0Stage IIIAT3
TCGA-BR-4267N0M0Stage IBT2a
TCGA-BR-4279N1M0Stage IIT2a
TCGA-BR-4280N1M0Stage IIIT2b
TCGA-BR-4361N0M0Stage IIIAT4
TCGA-BR-4368N2M0Stage IVT4
TCGA-BR-6452N0M0Stage IIAT3
TCGA-BR-6453N1M0Stage IIAT2
TCGA-BR-6454N0M0Stage IIAT3
TCGA-BR-6455N1M0Stage IIBT3
TCGA-BR-6456N1M0Stage IIBT3
TCGA-BR-6457N0M0Stage IIAT3
TCGA-BR-6458N1M0Stage IIBT3
TCGA-BR-6563N1M0Stage IIBT3
TCGA-BR-6564N2M0Stage IIIAT3
TCGA-BR-6565N0M0Stage IIBT4a
TCGA-BR-6566N0M0Stage IIAT3
TCGA-BR-6705N3aM0Stage IIIBT3
TCGA-BR-6706N1M0Stage IIIAT3
TCGA-BR-6707N0M0Stage IIAT3
TCGA-BR-6709N3aM0Stage IIIBT3
TCGA-BR-6710N0M0Stage IBT2
TCGA-BR-6801N0M0Stage IIAT3
TCGA-BR-6802N2M0Stage IIIAT3
TCGA-BR-6803N0M0Stage IIAT3
TCGA-BR-6852N0M0Stage IIAT3
TCGA-BR-7196N3aM1Stage IVT3
TCGA-BR-7197N0M0Stage IIT3

下面给家介绍一下,具体的分期

Diagram showing the T stages of bladder cancer




Pathologic TNM staging of thymoma and related entities, AJCC 8th edition
Definition / general
  • Applicable to thymoma, thymic carcinoma, thymic neuroendocrine tumors, combined thymic carcinoma
  • First introduced in AJCC 8th edition (Amin: AJCC Cancer Staging Manual, 8th Edition, 2017)
  • AJCC/TNM staging is used for predicting outcomes of thymic tumors, such as recurrence (in the lower stages) and disease specific survival (in the higher stages); reference numbers are available (J Thorac Oncol 2014;9:S65)
  • Pre operative clinical staging is based on physical examination and imaging; post operative clinical staging may be supplemented by pathological findings
  • Stage is determined primarily by levels of local invasion of a thymic malignancy into surrounding mediastinal structures (T classification) while nodal involvement and metastatic spread are much rarer events
  • There is no recommended histologic grading system for thymic tumors
  • Other staging systems also exist (Lung Cancer 2014;83:126)
Essential features
  • T, N and M categories are the mainstay for predicting recurrence and survival in patients with thymic tumors
  • Local invasion (T category) is the primary determinant of staging
Primary tumor (T)
  • TX: primary tumor cannot be assessed
  • T0: no evidence of primary tumor
  • T1: tumor encapsulated or extending into the mediastinal fat, may involve the mediastinal pleura
  • T1a: tumor with no mediastinal pleura involvement
  • T1b: tumor with direct invasion of mediastinal pleura
  • T2: tumor with direct invasion of the pericardium (either partial or full thickness)
  • T3: tumor with direct invasion into any of the following: lung, brachiocephalic vein, superior vena cava, phrenic nerve, chest wall or extrapericardial pulmonary artery or veins
  • T4: tumor with invasion into any of the following: aorta (ascending, arch or descending), arch vessels, intrapericardial pulmonary artery, myocardium, trachea, esophagus

Notes:
  • Involvement must be microscopically confirmed in pathological staging, if possible
  • T categories are defined by levels of invasion; they reflect the highest degree of invasion regardless of how many other (lower level) structures are invaded
  • T1, level 1 structures: thymus, anterior mediastinal fat, mediastinal pleura
  • T2, level 2 structures: pericardium
  • T3, level 3 structures: lung, brachiocephalic vein, superior vena cava, phrenic nerve, chest wall, hilar pulmonary vessels
  • T4, level 4 structures: aorta (ascending, arch or descending), arch vessels, intrapericardial pulmonary artery, myocardium, trachea, esophagus
Regional lymph node (N)
  • NX: regional lymph nodes cannot be assessed
  • N0: no regional lymph nodes metastasis
  • N1: metastasis in anterior (perithymic) lymph nodes
  • N2: metastasis in deep intrathoracic or cervical lymph nodes

Note:
  • Involvement must be microscopically confirmed in pathological staging, if possible
Distant metastasis (M)
  • M0: no pleural, pericardial or distant metastasis
  • M1: pleural, pericardial or distant metastasis
  • M1a: separate pleural or pericardial nodule(s)
  • M1b: pulmonary intraparenchymal nodule or distant organ metastasis
AJCC prognostic stage grouping
Stage I:T1a, T1bN0M0
Stage II:T2N0M0
Stage IIIA:T3N0M0
Stage IIIB:T4N0M0
Stage IVA:any TN1M0
any TN0, N1M1a
Stage IVB:any TN2M0, M1a
any Tany NM1b
Board review question #1
A 62 year old man presented with a large thymic carcinoma directly invading pericardium and no metastatic spread. What is the pT category per the AJCC/TNM 8th edition?

  1. pT1a
  2. pT1b
  3. pT2
  4. pT3
  5. pT4
Board review answer #1
C. pT2
Board review question #2
What is the major predictor of thymic carcinoma recurrence?

  1. Distant metastasis
  2. Extent of local invasion
  3. Histological type
  4. Nodal metastasis
  5. Size of tumor




https://en.wikipedia.org/wiki/TNM_staging_system

更多:https://www.pathologyoutlines.com/topic/mediastinumthymomastaging.html


更多生物信息课程:

1. 文章越来越难发?是你没发现新思路,基因家族分析发2-4分文章简单快速,学习链接:基因家族分析实操课程基因家族文献思路解读

2. 转录组数据理解不深入?图表看不懂?点击链接学习深入解读数据结果文件,学习链接:转录组(有参)结果解读转录组(无参)结果解读

3. 转录组数据深入挖掘技能-WGCNA,提升你的文章档次,学习链接:WGCNA-加权基因共表达网络分析

4. 转录组数据怎么挖掘?学习链接:转录组标准分析后的数据挖掘转录组文献解读

5. 微生物16S/ITS/18S分析原理及结果解读OTU网络图绘制cytoscape与网络图绘制课程

6. 生物信息入门到精通必修基础课:linux系统使用perl入门到精通perl语言高级R语言画图

7. 医学相关数据挖掘课程,不用做实验也能发文章:TCGA-差异基因分析GEO芯片数据挖掘 GEO芯片数据不同平台标准化 、GSEA富集分析课程TCGA临床数据生存分析TCGA-转录因子分析TCGA-ceRNA调控网络分析

8.其他,二代测序转录组数据自主分析NCBI数据上传二代测序数据解读

9.更多课程可点击:组学大讲堂视频课程

  • 发表于 2019-11-29 13:19
  • 阅读 ( 17448 )
  • 分类:TCGA

你可能感兴趣的文章

相关问题

0 条评论

请先 登录 后评论
omicsgene
omicsgene

生物信息

698 篇文章

作家榜 »

  1. omicsgene 698 文章
  2. 安生水 347 文章
  3. Daitoue 167 文章
  4. 生物女学霸 120 文章
  5. xun 82 文章
  6. 红橙子 78 文章
  7. rzx 74 文章
  8. CORNERSTONE 72 文章