B/T细胞分类:

B细胞分类:



初始B细胞 naive B (Bn cells)、记忆B细胞memory B (Bm)增殖B细胞(proliferative B cells),生发中心B细胞germinal center B (Bgc)、循环B细胞(cycling B cells)和抗体分泌B细胞(antibody-secreting cells ASC


attachments-2024-07-Lq7VsYf666a339a221e66.png

Bn cells:   IGHD/TCL1A

Bm cells:  CD27/TNFRSF13B

Bgc cells:  BCL6/AICDA

ASCs:       MZB1

cycling B cells:  MKI67


参考文献

DOI:https://doi.org/10.1016/j.cell.2024.06.038



attachments-2024-07-L4jQ6KyO66a1ddf928b56.png


Tang, F., Li, J., Qi, L., Liu, D., Bo, Y., Qin, S., Miao, Y., Yu, K., Hou, W., Li, J., Peng, J., Tian, Z., Zhu, L., Peng, H., Wang, D., & Zhang, Z. (2023). A pan-cancer single-cell panorama of human natural killer cells. Cell186(19), 4235–4251.e20. https://doi.org/10.1016/j.cell.2023.07.034 (北京大学张泽民团队揭示泛癌种自然杀伤细胞异质性)


Cheng, S., Li, Z., Gao, R., Xing, B., Gao, Y., Yang, Y., Qin, S., Zhang, L., Ouyang, H., Du, P., Jiang, L., Zhang, B., Yang, Y., Wang, X., Ren, X., Bei, J. X., Hu, X., Bu, Z., Ji, J., & Zhang, Z. (2021). A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells. Cell184(3), 792–809.e23. https://doi.org/10.1016/j.cell.2021.01.010


Zheng, L., Qin, S., Si, W., Wang, A., Xing, B., Gao, R., Ren, X., Wang, L., Wu, X., Zhang, J., Wu, N., Zhang, N., Zheng, H., Ouyang, H., Chen, K., Bu, Z., Hu, X., Ji, J., & Zhang, Z. (2021). Pan-cancer single-cell landscape of tumor-infiltrating T cells. Science (New York, N.Y.)374(6574), abe6474. https://doi.org/10.1126/science.abe6474 (张泽民课题组描绘泛癌T细胞全景图


Yang, Y., Chen, X., Pan, J., Ning, H., Zhang, Y., Bo, Y., Ren, X., Li, J., Qin, S., Wang, D., Chen, M. M., & Zhang, Z. (2024). Pan-cancer single-cell dissection reveals phenotypically distinct B cell subtypes. Cell, S0092-8674(24)00712-8. Advance online publication. https://doi.org/10.1016/j.cell.2024.06.038 张泽民课题组描绘泛癌B细胞全景图









  • 发表于 2024-07-25 09:50
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